PKPDsim - Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations
Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).
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odepharmacodynamicspharmacokineticspharmacometricscpp
9.63 score 51 stars 111 scripts 602 downloadsvpc - Create Visual Predictive Checks
Visual predictive checks are a commonly used diagnostic plot in pharmacometrics, showing how certain statistics (percentiles) for observed data compare to those same statistics for data simulated from a model. The package can generate VPCs for continuous, categorical, censored, and (repeated) time-to-event data.
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9.46 score 37 stars 9 dependents 411 scripts 1.2k downloadsclinPK - Clinical Pharmacokinetics Toolkit
Provides equations commonly used in clinical pharmacokinetics and clinical pharmacology, such as equations for dose individualization, compartmental pharmacokinetics, drug exposure, anthropomorphic calculations, clinical chemistry, and conversion of common clinical parameters. Where possible and relevant, it provides multiple published and peer-reviewed equations within the respective R function.
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clinical-researchpharmacokinetics
6.47 score 32 stars 68 scripts 411 downloads